The combination of radio-colloids and the blue dye method can significantly improve the detection rate of SLNB, which is the best method recognized in the clinic 3. The biggest problem of SLNB using blue dye alone is that its detection rate is only 70–86%. Blue dye, radio-colloids, or both can be used to identify the sentinel lymph node 1, 2. Sentinel lymph node biopsy (SLNB) for axillary lymph node staging in early breast cancer has been widely recognized. No adverse reactions were observed in this study, but larger studies are needed to properly assess the adverse reaction rate. This prospective clinical study suggests that SLNB using fluorescein and ultraviolet LED light is feasible in breast cancer patients. There was no significant difference in biopsy results between the two groups. In group B, Sentinel lymph nodes of breast cancer were detected in 52 patients, with a detection rate of 92.9% (52/56), a false-negative rate of 7.5% (3/40). In group A, Sentinel lymph nodes of breast cancer were detected in 63 patients, with a detection rate of 94.0% (63/67), a false-negative rate of 7.5% (4/53). No local or systemic reactions were observed in the two groups. The efficacy of Indocyanine green (ICG) combined with methylene blue (group A) and fluorescein combined with methylene blue (group B) in SLNB of breast cancer was compared, complications were observed at the same time. In this study, a total of 123 patients with breast cancer were divided into group A (n = 67) and group B (n = 56). We aimed to evaluate the feasibility and safety of fluorescein for SLNB in breast cancer. As a new tracer, fluorescent tracer technology has attracted much attention. The reagents and equipment required in the process of the combined method are complex and expensive, so there are certain restrictions in the use of primary medical institutions.

The combination of radio-colloids and dye method is the best method recognized.

Sentinel node